Biggest March Madness Upsets: Biggest Spread Upsets in Tournament History
BETMGMNorfolk State’s win over Missouri in the First Round of the 2012 NCAA Tournament is the biggest March Madness betting upset ever. As a 15-seed, the Spartans were a 21-point underdog before shocking the Tigers, 86-84, for the first (and only) NCAA Tournament win in program history.
UMBC’s upset of Virginia in 2018 is the second-biggest NCAA Tournament upset ever.
Biggest March Madness Betting Upsets Ever
| Year | Underdog | Favorite | Spread |
| 2012 | (15) Norfolk State | (2) Missouri | +21 |
| 2018 | (16) UMBC | (1) Virginia | +20.5 |
| 1997 | (15) Coppin State | (2) South Carolina | +19 |
| 2022 | (15) Saint Peter's | (2) Kentucky | +18 |
| 2001 | (15) Hampton | (2) Iowa State | +17.5 |
| 2016 | (15) MTSU | (2) Michigan State | +16.5 |
| 2021 | (15) Oral Roberts | (2) Ohio State | +16.5 |
| 1999 | (15) Weber State | (2) North Carolina | +15 |
| 2010 | (14) Ohio | (2) Georgetown | +14 |
| 2015 | (14) UAB | (3) Iowa State | +14 |
| 2005 | (14) Bucknell | (3) Kansas | +13 |
